Virgin Atlantic is restarting flights to San Francisco, Orlando and Las Vegas after an 18 months hiatus due to the pandemic.
The US west coast city will see flights resume tomorrow (Saturday) from Heathrow.
Daily flights to Orlando and Las Vegas come back in November.
Expansion to the Caribbean sees new routes from London to St Vincent on October 13 and The Bahamas on November 20.
An additional new route between London and St Lucia starts on December 18.
Flights from Manchester to Islamabad restart on October 8, followed by Orlando and New York in November and Atlanta in December.
The airline’s first long-haul route from Edinburgh to Barbados starts on December 5.
Chief commercial officer Juha Jarvinen said: “As global travel restrictions ease and connecting passengers with loved ones and colleagues becomes a reality, we’re looking forward to welcoming customers back on board and transporting them to a wider range of our destinations.
“From the thrills and spills of Orlando, the stunning scenery of San Francisco and the inviting beaches of the Caribbean, to reconnecting friends and relatives between London and Manchester and Pakistan, I’m delighted our customers can take advantage of our expanded route network, as we fly our customers safely once again.”