Spanish budget carrier is to restart flying from Heathrow in addition to Gatwick.
The airline, part of International Airlines Group which includes British Airways, is to serve Barcelona El Prat and Paris Orly from the west London hub from April 7.
Vueling last operated out of Heathrow in March 2020 with a route to La Coruna in Spain.
“This marks a significant expansion of the airline’s footprint beyond its main UK hub at London Gatwick,” Vueling said in a statement.
Barcelona El Prat airport – Veuling’s primary hub – will be served with two flights a day in addition to eight daily flights from Gatwick.
The Paris Orly route is new to Heathrow and is being introduced in time for the upcoming Olympic Games in France. Daily flights will be offered by Vueling.
Lead-in single fares on both routes from Heathrow start at £30.44.
Chief commercial, customer, network and strategy officer Carolyn Prowse said: “We are delighted to relaunch operations from London Heathrow, UK’s largest airport.
“These two new routes are in addition to our existing operation from London Gatwick and positions Vueling as one of the key airlines connecting these major hubs across Europe.
“Barcelona is our largest hub and we will now offer up to 10 daily flights from London overall; and Paris Orly, is our second largest operating base, and is currently not served from Heathrow at all.
“This relaunch has been possible thanks to our strong collaboration with British Airways.”