New Lufthansa offshoot City Airlines is to serve Birmingham and Manchester as part of its launch network this summer.
Founded last year by the German airline group, City Airlines will run short and medium-haul routes from hubs in Munich and Frankfurt while also operating feeder flights for Lufthansa.
The first destinations to be served from Munich include the two UK regional airports as well as Bordeaux and German domestic services covering Berlin, Hamburg, Bremen, Düsseldorf, Cologne and Hanover.
Lufthansa City Airlines will start operations with four Airbus A319s but the company has ordered 40 A220s plus purchase options on a further 20 aircraft.
Flights will be available to book from the end of April.
The carrier said: “The competitive strengthening of the short-haul network is essential for strengthening the Lufthansa Group’s market position and the planned growth of Lufthansa long-haul routes.
“Passengers on board Lufthansa City Airlines can expect the Lufthansa product offering and customer experience for short and medium-haul routes.
“The first two of four Airbus A319 aircraft to be deployed this year have already been painted in the new Lufthansa City livery.”
Lufthansa City Airlines will gradually expand its network and offer further destinations in Europe in the following months, according to the parent company.