Boston, Los Angeles, San Francisco and Washington DC will be served from Gatwick this summer by long-haul low-cost carrier Norse Atlantic Airways.
The new transatlantic routes are in addition to services already scheduled to Fort Lauderdale and Orlando from May and an existing New York service.
The airline will operate up to 36 flights a week between Gatwick and seven US destinations.
Gatwick will offer 90 flights a week to a total of ten US destinations this summer.
The new Norse Atlantic schedule will see six flights a week to Washington, a daily frequency to Los Angeles, three fights a week to San Francisco and five flights a week to Boston.
Lead-in return fares to Boston start at £370, San Francisco at £410 and Los Angeles and Washington at £430.
Washington will be served from June 1, Los Angeles from June 30, San Francisco from July 1 and Boston from September 2.
The additional four North Atlantic routes help fill a void for US flights at Gatwick left with Virgin Atlantic moving operations to Heathrow during the pandemic.
Chief executive Bjorn Tore Larsen said: “This marks an important day for the UK aviation industry and for consumers as we celebrate serving more destinations to the US from London Gatwick this summer than any other airline.
“The addition of direct flights to Los Angeles, San Francisco, Washington, DC and Boston to our already popular New York, Orlando and Fort Lauderdale/Miami services will provide greater choice and value for consumers.”
He added: “The Norse team are disruptors. We look forward to making our unbeatable product available to even more customers this summer, as we build the industry’s first successful low cost long haul airline.
“We have made a significant investment in our UK airline, based at Gatwick airport, and now employ over 370 colleagues at our London base.
“I am very pleased that we are fulfilling our pledge to create competition in the transatlantic market that will benefit consumers, stimulate business travel and lead to job creation on both sides of the Atlantic.”
Gatwick chief executive Stewart Wingate said: “Long-haul routes, particularly in North America, are a hugely important aspect of our strategy, especially as we look to return to pre-Covid levels of passengers and destinations.
“For Norse to demonstrate such commitment to Gatwick highlights the incredibly strong demand for our slots and we look forward to welcoming more long-haul routes in coming months.”