Marella Cruises is to run fly-sailings from the US for the first time in summer 2021.
The Tui UK and Ireland cruise brand will deploy the ship Marella Discovery to Port Canaveral in Florida to run four itineraries covering 11 new ports of call.
Seven and 14-night options with flights from five UK airports go on sale on November 7.
Destinations include New York, the Bahamas, Caribbean plus New Orleans and Tampa and Miami as part of a 12-night re-positioning voyage.
Cruise and stay packages will be available in Orlando for Walt Disney World and Universal Orlando Resort.
Tui UK and Ireland cruise managing director Chris Hackney said: “We’re really excited to be setting sail from the USA, expanding our programme provides an opportunity for cruisers to sample the American Dream, and we’ve ensured there really is something for everyone.
“Whether that’s a visit to Walt Disney World in Florida, an evening in New York, authentic jazz music in New Orleans or a rollercoaster in Busch Gardens.
“Offering our customers more choice and flexibility is at the heart of what we do, which is why customers will also benefit from regional flights from five airports.”