Loganair is to withdraw Glasgow to Southend flights in the new year.
The route will be axed from January 3, 2020.
The Scottish carrier “apologised for any inconvenience to customers who have booked to travel on the route” after this date.
They will be contacted and offered a full refund or a re-book option with an alternative carrier.
The announcement came less than 24 hours after Flybe announced plans to serve both Glasgow and Edinburgh from the Essex airport from March 29 next year.
A Loganair spokesman said: “The feedback from our customers regarding both the passenger journey through London Southend airport and the Loganair travel experience has been incredibly positive.
“We’ve made this decision, after much deliberation, due to the high number of low-fare options available in the Glasgow to London market for which our size of aircraft are unsuitable.
“As a result, we are able to improve our service from Glasgow to East Midlands.
“From 24 February Loganair will operate three times a day Monday through Friday, leaving Glasgow at 6.55, 14.45 and 18.15, thereby increasing travel options for both business and leisure travellers.”