Chicago is the latest US city to gain a low-cost air link from the UK.
Icelandic carrier Wow Air is to operate via Reykjavik this summer from Gatwick, Bristol and Edinburgh.
Fares start at £139 one-way on the service which starts on July 13 and will run four times a week.
The addition of Chicago builds on a transatlantic network which includes services to Pittsburgh, New York, Washington DC, Boston, Montreal, Toronto, Los Angeles, San Francisco and Miami.
Airline founder and chief executive, Skúli Mogensen, said: “I’m thrilled to add Chicago as our 10th North American destination, offering ultra-low fares to UK travellers who may not have previously considered travel to this exciting city viable.
“This is our fourth new long haul route announcement in just a few months, bringing our network now up to a total of 32 destinations
“As the third largest metropolitan area in the US with a record number of visitors last year, there’s never been a better time to visit Chicago and we’re excited to see the response to our new route.”
The flights from Reykjavik to Chicago will be served by Airbus A321 aircraft with a flight time of 6 hours 40 minutes, departing on Mondays, Wednesdays, Thursdays and Saturdays.
The approximate total journey time from Gatwick will be 11 hours, including a stopover in Iceland.