400 senior cabin crew jobs are being cut by British Airways on both long and short-haul routes.
All the redundancies will be voluntary and a 90-day consultation process has started, the BBC reported.
The first cuts are expected to take effect from next March.
BA said the job cuts would affect senior cabin crew staff who worked exclusively on either its long or short-haul flights, and not those who worked across both.
The airline has about 14,000 cabin crew staff in total.
BA was hit by a series of strikes over staffing levels, pay, and the removal of travel concessions in 2010 and 2011.
BA’s sister airline Iberia is moving ahead with plans to shed 4,500 jobs despite protests from unions in Spain.