Germanwings expects get more than 80% of passengers to their destination in face of a strike by pilots.
More than 60% of all scheduled flights are to operate during the 24-hour industrial action which is due to take place from 11pm tonight (Thursday).
The airline had previously warned that around 900 flights would be affected by the walkout by pilots union VC Cockpit.
Germanwings management will fly aircraft, other aircraft and crew have been leased in from other airlines and passengers have been rebooked on other flights operated by partner carriers Lufthansa, Swiss and Austrian Airlines.
A replacement schedule is in place with passengers advised to check the status of their flights on germanwings.com/flightstatus
Passengers on cancelled flights can rebook rail connections within Germany or cancel or re-book their flight free of charge.
“Germanwings apologises for any inconvenience caused to passengers by this industrial action, and is striving to keep its effects to a minimum,” the airline said.