British Airways has announced a twice-weekly summer service from Heathrow to Charleston from April 2019.
The route will be the only direct connection between Europe and the southern US city.
It will be operated by a Boeing 787-8 Dreamliner and will run on Thursdays and Sundays. Return fares start from £600.
It takes the number of BA routes from London to the US up to 29 as the airline prepares to take delivery of 12 Boeing 787-10s between 2020 and 2023.
Sean Doyle, British Airways’ director of network and alliances, said: “You can’t help but get sucked in to the old-world charm of Charleston; its cobblestone streets, colourful houses and historical buildings make it a unique city. Recently we launched flights to Nashville and New Orleans and earlier this year announced a new route to Pittsburgh. Travelling to the states is as popular as ever, so we’re really pleased to be adding this charming city to our extensive global network and giving customers even more choice of holiday destinations.”