American Airlines will axe flights from Stansted to New York JFK on July 2 as part of cuts announced last week to cope with the record fuel price.
The airline only launched from Stansted in October 2007 and had previously said the service was safe despite a concentration of operations at Heathrow.
American said the service would end as part of a first round of reductions in a cost-cutting programme that will see up to 45 mainline aircraft grounded.
The carrier is the world’s biggest and chief executive Gerard Arpey called on other airlines to follow suit last week, saying: “The airline industry was not built to withstand oil prices at $125 a barrel.”
Passengers booked on Stansted services will be offered alternatives flights from Heathrow.
The cancellation of the service is a fresh blow to Stansted following the collapse of business-only carrier Eos which flew from the airport. Stansted strategy director Nick Barton said: “We are obviously disappointed, but the decision reflects the global situation. We continue to work with airlines keen to commence services from Stansted.”