A Danish airline plans to start low fare transatlantic flights from Stansted and Birmingham next year.
Primera Air plans to serve Newark and Boston from April 2018.
The airline will offer a daily service from both airports to New York’s Newark airport and four a week to Boston from May.
Flights to both destinations go on sale today with prices starting at £149 one-way inclusive of taxes, fees and charges
Another transatlantic route from Stansted and two more from Birmingham are to be announced by the end of the summer.
Flights will be operated by new Airbus A321neo aircraft with full-service premium and low-fare economy cabins, free wi-fi and onboard charging points.
Primera Air will be the first airline for nine years to fly scheduled services to the US from Stansted.
The carrier operates flights to more than 70 destinations in Europe with bases in Denmark and Latvia.
The airline is part of the Primera Travel Group that operates travel agencies and tour operations in Sweden, Denmark, Norway, Finland, Iceland and Estonia.
Primera Air plans to increase its presence at Stansted over the next two years. The airline has 20 Boeing 737 MAX 9-ER aircraft on order.
Airline president and chairman Andri Ingolfsson said: “We are very proud to announce our new base at London Stansted and routes to the USA.
“With our brand new Airbus A321neo aircraft, we are opening routes previously traditionally served only by wide-body aircraft.
“With unmatched efficiency of these new-generation aircraft, we will be able to offer unprecedented prices to our passengers from London Stansted to the USA.
“At the same time, we are very proud to be offering a low-fare/high quality product and service concept, that will be perfect both for leisure and business travellers.”
Stansted chief executive Andrew Cowan added: “We’re thrilled Primera Air has chosen London Stansted as its UK base for these exciting and innovative new long-haul services to the USA.
“We know from our customers that there is enormous demand for flights to New York and Boston from London and the east of England, so the arrival of Primera Air is fantastic news for both business and leisure passengers wanting great value, excellent service and the convenience of flying transatlantic from their local airport.
“The welcome arrival of Primera Air to Stansted offers passengers even more choice and provides great new transatlantic connections to New York and Boston – both of which are important destinations for businesses in our catchment. I’m sure these new services will prove to be really popular and we look forward to working with Primera Air to add more routes in the future.”