The Lake District is losing air links less than a year after Carlisle airport re-opened to passenger services.
All scheduled Loganair flights to Southend airport and Belfast City will be suspended from March 27 until further notice as a direct result of the impact of coronavirus.
A route to Dublin by the Scottish carrier was suspended last week.
Loganair customers will be informed by email today and fares will be refunded automatically, according to the Cumbrian airport.
Carlisle Lake District airport managing director Simon Williamson said: “The unprecedented situation that we are all facing is having a major impact, with government advising against all unnecessary travel.
“This decision reflects that important advice. Our priority must continue to be the health, safety and wellbeing of our employees, guests and the local community.”
He added: “Loganair has strongly advised that affected customers do not call their call centre as they are experiencing very high volumes of calls.
Loganair has updated its website with all relevant information and those affected are advised to visit www.loganair.co.uk instead.
“We also want to take this opportunity to thank all our employees for their hard work during recent weeks, from implementing action plans to working to ensure the safety of all passengers and colleagues.
“The world as a whole is experiencing exceptional challenges right now and we appreciate your support and understanding.”