Dublin is being added by Eastern Airways as a new route from Southampton airport as part of expansion plans following the demise of Flybe.
Flights are set to start on August 17, re-connecting the south coast airport with the Irish capital.
An initial daily frequency is due to rise as demand increases following the return to air travel following the Covid-19 travel restrictions.
Services to Belfast City, Leeds-Bradford, Manchester, Newcastle and Teesside are already offered by the regional carrier as it develops its Southampton base with 72-seat ATR72-600 aircraft.
The Southampton-Manchester route returns to twice-daily flights from August 3 and Newcastle from September 7 as initial increases in the coming weeks.
The airline intends to have up to five Embraer and ATR 72-600 aircraft based at Southampton.
Flights to Dublin start at £69 one-way.
Eastern Airways commercial and operations general manager
Roger Hage said: “We are delighted to confirm a start date for the Southampton–Dublin route launch of August 17, which is now bookable, as we restore this important trade and leisure link between the south coast of England and Ireland’s capital.
“We are beginning to help increase accessibility to Southampton as we have already reintroduced a number of other routes from the airport, increasing frequency and will also add further new services as we establish a five aircraft base.
Airport operations director Steve Szalay added: “Dublin has long been a destination in high demand by our passengers.
“We are delighted that Eastern Airways is opening this route from Southampton airport, once again demonstrating how crucial regional airports are in providing vital connectivity across the UK.”