Almost 30,000 more people used Manchester airport last month than in April 2014 to bring the total up to 1.7 million.
The rolling annual total of passengers now stands at a record 22.3 million, up 6.7% year-on-year.
A busy Easter period and an increase in long-haul routes were key drivers of growth.
April saw Virgin Atlantic take over Delta Air Lines’ Atlanta service and add a larger aircraft to the route.
Thomas Cook Airlines has just started new direct services to Miami and New York and plans flights to Los Angeles and Boston in 2016.
Airport managing director, Ken O’Toole, said: “Manchester airport’s growth continues and we are already looking ahead to a busy summer schedule.
“Over the next few months, we look forward to adding further new routes and frequencies to our offering to ensure that the 22 million people who live within a two hour drive of the airport have a greater choice than ever before.
“With two full length runways, Manchester airport is, and will continue to have, the available capacity and demand to meet the needs of our airlines and passengers.
“In addition, the recent abolition of Airport Passenger Duty for children under 12 means family summer holidays are more affordable. This is good news for passengers, the airport and the local economy.”