Thomas Cook Airlines’ first flight from Manchester to Boston took off yesterday.

The service will run twice a week until the middle of September, giving the opportunity for long weekends in the US east coast city.

Boston flights from Manchester are available from around £349 return for economy and £609 for premium class.

Departures are on Monday afternoons and Friday mornings, with inbound flights to the UK landing early on Tuesday and Saturday mornings.

Thomas Cook chief airlines and hotels officer, Christoph Debus, said: “This route opens up great new possibilities for our customers to enjoy long weekends in one of the America’s greatest cities.

“The three-night stay is short enough to dodge jet-lag, the city is close enough for a long weekend, it’s affordable even in premium class, and our £100 million refurbished interiors are comfortable enough to rest on the way back home to work.

“This is our second inaugural flight to the US route in May, with our Los Angeles programme now four weeks old and our schedule for Boston makes it ideal for a long weekend.”

Manchester airport commercial director, Stephen Turner, said: “This route makes Manchester the only UK airport outside of London to offer a direct service to Boston, and offers our 23.5 million annual passengers easy access to the USA.

“Furthermore, it showcases the role Manchester airport plays in UK aviation, offering a wealth of long haul destinations, which no other UK airport outside of London has.

“I am sure this route will be a success and hope all the passengers on the first flight have a great trip to the USA.”