United Airlines is to drop flights from Newcastle to New York (Newark) at the end of the summer.
The last seasonal transatlantic flight from the north-east airport will operate on September 6.
The US carrier is running six flights a week and has offered the service for two summers.
Newcastle airport interim chief executive, Nick Jones, said: “We understand that this will be very disappointing news.
“We, United Airlines and our regional partners really have given the New York route our best possible shot during its seasonal period of operation.
“Passenger numbers in 2016 have been higher than in 2015, but with great regret we understand United’s decision.”
He added: “We would like to thank all of our customers who have used the service.
“We continue to have numerous connections for business travellers to the US via our Heathrow, Amsterdam, Paris, Dublin and other hub services, regular Thomson flights to Orlando and Cancun, as well as seasonal leisure flights to New York with Jet2.com, and we will continue to explore future opportunities for transatlantic flights.
“Newcastle international airport remains very strong, with passenger numbers growing, and a number of new routes, including Berlin, Warsaw and Gdansk, recently announced.
“This news regarding the New York service is certainly not reflective of the general trend at the airport.”
Iain Malcolm, leader of South Tyneside Council, said” “This is disappointing news.
“The region pulled together magnificently to secure a New York service, and we have all worked extremely hard to make it work.
“While it is a blow to lose the service, especially given that numbers were up, the reasons are understandable.
“Newcastle international airport, however, remains in good shape with strong growth in passenger numbers and a significant number of new services announced recently.”