Cleveland in Ohio is being added by Aer Lingus to its transatlantic network for next summer.
Flights from Dublin start of May 19, 2023, with connections from nine UK airports.
The airline’s 15th North Atlantic service will run four times a week using two class Airbus A321neo LR aircraft.
The new route will give access to Great Lakes region of the US as the only direct European service to Cleveland.
Fares start at £249 each way as part of a return journey.
Are Lingus chief strategy and planning officer Reid Moody said: “This is a significant announcement for Aer Lingus as we deliver on our ambition to grow our transatlantic network.
“The commencement of a new route, accompanied with further network connectivity, is an exciting milestone for the airline during a critical time of recovery for our business.
“The new service to Cleveland not only provides a direct connection to Ireland but connections to over 20 popular European destinations via our Dublin hub.”
Dennis Kramer, Cleveland Hopkins airport interim airport director, added: “We are truly excited for the opportunity to have non-stop service for travellers to connect to Ireland and the many other European destinations.
“Our team has worked for years to bring this route to Cleveland for our community.”