Jet2CityBreaks has restarted its programme from Manchester airport with flights to Barcelona and Rome.
More city destinations will be added in the winter.
These include Reykjavik, Budapest, Prague and Vienna as well as a programme of Christmas markets trips.
The operator first started running a dedicated city breaks programme in May 2015 but it was disrupted due to the pandemic and changing overseas travel restrictions.
Steve Heapy, chief executive of Jet2 and Jet2CityBreaks said: “The demand for city breaks is returning very strongly and comes at the perfect time to get away to and explore Europe’s best cities.
“The restart of our award-winning city breaks programme is another step towards a real and meaningful restart of international travel.
“We still have some way to go, but we are looking ahead with real confidence and optimism as we know how much customers want to get away and enjoy themselves.”