Thomas Cook is to serve eight new destinations next summer from Luton airport.
The destinations being added from the base of collapsed Monarch include Palma, Dalaman and Corfu.
Sun Express has also increased its number of destinations from one to four, including routes to Antalya and Ankara.
El Al will be running an additional flight to Tel Aviv every Sunday until March 2018.
A total of 22 new routes have been added from Luton so far this year, bringing the network up to more than 130 destinations across Europe, Asia and Africa.
The news came as the airport revealed a 3% rise in passengers in October to more than 1.4 million over the same month last year.
The airport has embarked on a £150 million redevelopment project designed to raise annual capacity by 50% to 18 million passengers by 2020.
However, Luton needs improved public transport links to make it quicker and easier for travellers to use the airport.
The airport is calling for an express-style rail service from central London to help ensure it can play its role in delivering much-needed capacity as the government continues to debate the expansion of London airports.
Chief executive, Nick Barton, said: “We continue to welcome more travellers, introduce new routes and improve the experience we give passengers as they pass through the airport.
“We are very pleased that our airlines are expanding their offering and we are looking forward to welcoming more passengers whether they are travelling for business or pleasure.”