Indian carrier Jet Airways is to start serving Mumbai from Manchester airport.
Four flights a week will run from November 5 with a 254-seat Airbus A330-200.
Departures are scheduled for Mondays, Thursdays, Saturdays and Sundays.
Manchester airport chief executive, Andrew Cowan, said: “We have worked, along with a range of partners, to create a compelling case for why our city – and the wider North – is a great place to visit, invest in and do business with.
“I am delighted Jet Airways have recognised this by launching what I’m sure will be a hugely popular service.
“This route will deliver a major boost to businesses looking to export to the world’s fastest-growing economy, as well as helping to attract Indian visitors and investors to the North.”
The new service will complement the carrier’s existing three flights a week from Heathrow to Mumbai and a daily service between London and Delhi.
Jet Airways chief executive Vinay Dube said: “We are extremely pleased to begin a new chapter in our decade-long relationship with the United Kingdom.
“The new service will bring Manchester into our global network, reinforcing our footprint as well as expanding the choice of connectivity to and from the United Kingdom for our guests with the four days a week, non-stop service.
“With the new flight, Jet Airways will have over 8,000 seats on offer every week, making it increasingly convenient for both business as well as leisure travellers between India and the UK, deepening commerce as well as tourism ties between the two countries.”