Newcastle gains a direct air link with London City airport from Monday.
Flybe franchise partner Eastern Airways will run a double-daily service with a 70-minute flight time each-way.
The new route gives Newcastle airport a second option for travel to the capital in addition to existing British Airways flights to Heathrow.
Fares start at £79.99 one way.
London City airport aviation director Peter Downes said: “As the ninth domestic route to join our route network, as part of existing Aberdeen operations, London City continues to ensure the UK regions are connected straight into capital, and vice versa.”
Eastern Airways commercial and operations general manager
Roger Hage said: “We are very pleased to launch this new direct central London air service on behalf of Flybe, adding to their expanding London City network and to the Aberdeen–London City service we already operate.
“We believe it’s vital for major UK cities to have direct fast convenient air links between the regions and City of London.
“This route provides a direct link for our customers from Newcastle and the north-east region, from where they can quickly access Canary Wharf, the City of London and the underground network with ease, helping business and leisure travellers alike.”
Newcastle airport chef operating officer Richard Knight added: “For a number of years, we have received countless requests for a direct route into the heart of London – so we are thrilled to be launching this service.
“With a flight time of just over an hour, complementary on-board service and the airport’s low security-queuing times, the north-east travelling public will be able to access the London market quickly and efficiently thanks to the new route.”