Mayor of London Boris Johnson is to rule on plans to develop the capital’s first cruise terminal.
Work is due to start at the end of 2011and is expected to take four to five years, subject to approval.
But developers hope the terminal will be completed in time for the 2012 Olympic Games.
Enderby Wharf will provide a dock for cruise ships and the Thames Clipper commuter riverboat service, along with a 251-room hotel and 770 new homes.
Greenwich Council has already approved the plans designed to attract cruise ships with a maximum capacity of 1,500 passengers close to the O2 arena.
Enderby House, a Grade II-listed building, will be extended to provide tourist, community and retail facilities as part of the plan.
James Blakey, planning director at West Properties, said Greenwich was chosen out of 11 possible sites across London.
“The area has a rich maritime history and Enderby House was referenced in Moby Dick,” he said.
“At the heart of the proposals is the provision of an international cruise liner terminal in the maritime heartland of Greenwich and London.”
A Transport for London cable car link across the River Thames is also planned, linking the Greenwich Peninsula with the Royal Victoria Dock in Newham.
Greenwich council leader Chris Roberts said: “Both of these spectacular projects are unique ventures for a unique location which will further cement Greenwich Peninsula’s reputation as a world-class destination.
“It takes a special place to play host to projects of this level and they will draw millions more visitors into an area which is already a World Heritage site and home to the world’s most popular entertainment venue, The O2.”