British Airways subsidiary BA CityFlyer plans to resume flights from London City airport to Ibiza, Florence, Malaga and Palma this summer.
The airline will also be recommencing domestic flights to Edinburgh, Glasgow plus Dublin.
London Docklands airport suspended commercial operations on March 25, in response to the escalating Covid-19 public health crisis and government lockdown measures.
The first flight at the airport since then was a BA CityFlyer service from the Isle of Man on Sunday.
New measures put in place include rapid contact-free temperature checking technology, crowd monitoring, an enhanced cleaning regime using an anti-microbial surface treatment, and social distancing procedures such as one-way systems and Perspex screens.
Passengers will also be asked to wear face coverings in the airport.
Airport chief executive Robert Sinclair said: “The restart of some services at London City airport by our home-based carrier, British Airways, is good news for business and leisure passengers and we hope signals the start of the road towards a recovery.
“We believe there is demand from passengers to get back to flying and we have worked hard to make that possible – putting in place appropriate measures to make the airport safe and working closely with British Airways to restore some popular routes and important connections.
“We are looking forward to flights beginning to re-start and working with British Airways to grow passenger volumes and build on their route network in time as confidence returns.”