Seven new routes are being added by Wizz Air to an existing network of ten routes from Doncaster Sheffield airport.
The winter expansion will see the UK arm of the eastern European budget carrier serve destinations such as Alicante, Malaga, Larnaca and Faro.
The airline will allocate one Airbus A320 to the Yorkshire airport, making it the second UK base after Luton airport.
Other destinations bieng added from the end of October include Lublin in Poland, Kosice in Slovakia and Suceava in Romania with fares starting at £17.99 one-way.
The move create more than 36 direct jobs and over 110 jobs in the Doncaster area.
Wizz Air willl have 11 aircraft permanently based in the UK and the additional routes from Doncaster Sheffield means almost 1.8 million seats will be available on sale on 107 routes from the UK for the remainder of 2020.
The creation of this new base also follows recent announcements of new bases in Bacău, Dortmund, Lviv, Larnaca, Milan-Malpensa, Tirana, St Petersburg and the launch of more than 200 new routes across the network since April.
Wizz Air UK managing director Owain Jones said: “The creation of our second base in the UK is a major milestone for Wizz Air UK, and testament to both our long term commitment to serving the UK market and the strength of the Wizz Air business model, as we continue to expand our footprint during this challenging time for the industry.
“We’re delighted to be introducing new low-fare connections to Doncaster Sheffield, to provide customers with opportunities to explore new cultures and cities, or return to their favourite holiday spots.”
Airport chirman Robert Hough added: “With strong performance there is now a real possibility for the base to grow from one aircraft initially to a multi-aircraft base further broadening the range of routes available.
“There is no doubt that the aviation sector faces its greatest challenge in modern day history at this time. It is essential that the UK government acknowledges and supports airlines and airports that bring much needed investment into the UK economy. Doncaster Sheffield Airport contributes over £60 million to the Sheffield City Region and offers job security for