Eurostar is to start running direct London-Amsterdam services both way from October 26.
Return journeys currently involve a stop in Brussels for security checks.
The high speed passenger firm is putting tickets on sale for the direct return journey on September 1 leading in at £40 each way.
Travellers from Holland and Belgium currently need to self-isolate for 14 days on their return to the UK due to Covid-19 quarantine regulations.
However, Eurostar is offering flexible fares which can be exchanged with no fee up to 14 days before departure “in light of the continuing uncertainty and recently introduced quarantine measures”.
The flexible rates apply to all bookings made until December 31.
Passengers can plan ahead for trips over the Christmas period and up to February 2021 with tickets valid for up to six months ahead of travel.
The journey time from Amsterdam to London is four hours nine minutes and three and a half hours from Rotterdam.
A new seat map ensures passengers are seated at a safe distance apart respecting social distancing guidelines, according to the company.
“Trains are deep cleaned before every journey, and cleaning teams are on board to regularly disinfect high contact areas,” Eurostar said.
“All travellers must wear a mask on board and in stations, in line with government regulations.”