Unions have reacted with anger over the scale of the 2,500 job losses being imposed by Thomas Cook.
The cost cutting involves the closure of 195 agency branches and the loss of 16% of the 15,500 total workforce.
Shopworkers’ union Usdaw said: “The scale and severity of these redundancies will come as a real shock to our members.”
The Transport Salaried Staffs Association said it was “shocked and angry” at the scale of the job losses.
General secretary Manuel Cortes said: “This constant policy of slash and burn, with the axing of one in four stores and the loss of jobs, is simply self-defeating.
“The company needs new products if it to come to come to terms with the age of the internet and prosper in the 21st century.
“That is the only way to stop this spiral of decline which repeated bad management decisions over the past five years has led them.”
Having recently shut 149 stores, Cook will be left with 874 travel agencies across the UK and Northern Ireland.
It is due to confirm which stores are due to be closed later this week. Cook also plans to shut its Accrington office in a move affecting around 100 jobs.
Administrative and managerial jobs are also at risk across its head office in Peterborough and a site in Preston. Cook also has offices in Egham in Surrey, Brighton, and Birkenshaw, near Bradford.
Cook announced plans last summer to close a major office in the centre of Bradford. The call centre with 537 employees is due to close this month.