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British Airways is to resume service from London to Tehran in Iran this summer.
The airline will initially run six flights a week from July 14.
Frequency will rise to a daily service from winter 2016.
The airline will operate the route with a four-class Boeing 777 from Heathrow Terminal 5. The move follows the lifting of western sanctions against Iran last month.
Head of network planning, Neil Cottrell, said: “Iran is a large and growing economy and Tehran is a brilliant business city.
“The recent lifting of sanctions opens up exciting new prospects for Iran as a tourist destination.”
BA suspended flights in October 2012 following the takeover of BMI as the route was not seen to be commercially viable at the time.
Return fares start at £384 in economy, £728 in premium economy, £2,163 for business and £3763 for first class.