EasyJet expects today (Friday) to be the busiest day in its history as it carries more than 255,000 passengers.
The budget airline is to operate 1,600 flights across its network.
More than 147,000 passengers are due to fly to or from airports in the UK on over 930 flights.
The top destinations are Madrid, Malaga, Paphos, Barcelona, Athens and Gibraltar.
The record flying day comes as the airline moves to resolve a dispute with pilot members of the British Airline Pilots Association who are threatening to strike over fatigue.
Balpa said: “EasyJet have asked to meet us today, hopefully to try and resolve the current dispute over pilot fatigue.”
The airline’s UK director, Sophie Dekkers, said: “September has always been one of our busiest times of year and this year will be no exception.
“Every year, more and more people choose easyJet to take them on their late summer getaways or for business trips and this year has broken records once again.
“Whether customers are flying to enjoy a relaxing break, visiting friends and family or for work, we are doing everything possible to make our customer’s travel as easy and of course, affordable as possible.”