Latvian airlineAir Baltichas started flying between Manchester and Riga.
Two flights a week will serve the Latvian capital using Airbus A220 aircraft with fares starting at €29 one-way.
The Manchester connection adds to the airline’s other UK links to London, Edinburgh and Aberdeen.
Chief executive Martin Gauss said: “Riga is a dynamic city and the key business centre of the Baltic states and has a lot to offer to both business and leisure travellers.
“It is also a very convenient transfer point with excellent connections within our wide route network.
“Our expanding 2021 route map reflects the demand we see for destinations after the reopening of more countries for travellers.”
Manchester airport managing director Karen Smart added: “It is great to see Air Baltic commence flights to Riga from Manchester airport.
“As and when travel restrictions continue to ease, the route will offer great access to eastern Europe and beyond.
“We look forward to working closely with the team at Air Baltic as they grow and develop from Manchester airport.”