Heathrow and Manchester airports will be part of the summer flight schedule operated by Air Malta, from May until October.
The Maltese carrier plans to fly to 20 cities across Europe and has put more than half a million seats on sale.
During the peak season, the airline aims to operate up to 10 weekly services from the Mediterranean island destination to Heathrow, and twice-weekly services to Manchester.
Roy Kinnear, Air Malta’s chief commercial officer, said: “This schedule delivers a strong message of commitment by the airline towards the local and international tourism industry.
“The schedule focuses on Malta’s core markets for inbound tourism and is in line with Air Malta’s strategy of being a point-to-point carrier operating to major European cities and major airports attaching to larger network airlines through key interline partnerships and code-sharing agreements.”
More: Foreign Office drops advice against travel to some destinations
Malta opens up to British holidaymakers from June
David G Curmi, Air Malta’s executive chairman, added: “We are happy to note the gradual increase of consumer confidence and propensity to travel this summer.
“This increase, driven primarily by the success of the vaccination rollouts in many countries, especially in Malta, augurs well for an easing of travel restrictions and a restart in tourism this summer.”
Malta will be available to British holidaymakers vaccinated against Covid-19 from June 1.
Travellers who can show proof of full vaccination received at least ten days before arriving in the country will no longer have to provide a negative PCR test certificate 72 hours prior to, or on arrival.
Passengers will need to show their vaccination card when boarding to be accepted to travel.
The Foreign Office (FCDO) is no longer advising against non-essential travel to Malta.