The Italian lakes are being introduced by easyJet holidays for this summer and 2022.
A new programme features Como, Garda and Maggiore with packages leading in at £450 per person.
The holidays will be operated via flights to Milan, with the UK budget carrier claiming to offer more flights to the Italian gateway than any other airline.
EasyJet holidays commercial director Paul Bixby said: “The lakes are some of the most beautiful areas of Italy and we’re seeing them grow in popularity for holidaymakers looking for something a little bit different.
“With holidays available for this summer and bookable all the way through to next summer, we can’t wait to take our customers away of a discovery of the ultimate Italian glamour.”