Singapore Airlines’ non-stop Manchester-Singapore flights return on July 17.
The service will initially run three times a week with an Airbus A350-900.
But the airline hopes it can gradually increase frequency over time and also include the return of a transatlantic connection to Houston.
SIA UK and Ireland general manager Mohamed Rafi Mar said: “Manchester and the north-west region have been a key part of our route network for over 30 years, so while it was never our intention to have an enforced break in service as has happened due to the unprecedented Covid-19 pandemic, we are delighted to be able to make our return.
“As restrictions slowly ease, our dedicated Manchester staff are excited to welcome our customers back once more and we look forward to continuing our long-standing and deep connection with the city of Manchester and its surroundings.”
Manchester airport managing director Karen Smart added: “We are pleased to hear Singapore Airlines will be resuming its direct service from Manchester next month.
“Singapore Airlines is one of our longest serving airlines and we know its routes have been extremely popular with passengers from across the north over the years, both in terms of leisure and business travel.
“We look forward to working with our colleagues at Singapore Airlines to make this returning service a success, especially given the destination’s inclusion on the UK government’s green list.
“Together, we hope to be able to relaunch the popular Houston service as soon as possible once travel to and from the United States is opened up.”