Swiss is due to resume flights between London City airport and Zurich today (Wednesday).
The airline plans an initial two flights a week withbthe schedukle due to increase based on demand.
The Swiss natonal carrier expects to retore a route between London City and Geneva in August.
Switzerland has initially been placed in the amber category as part of the government’s traffic light system for reopening overseas travel from May 17.
This means that travellers from England will need to take a pre-departure test and PCR tests on days 2 and 8 on their return, and self-isolate at home for 10 days unless exempt.
The government will review the categories every three weeks.
This means that continued progress with the vaccination programmes in the UK and Switzerland could see quarantine-free travel introduced between the two countries in June, according to London City.
Zurich was the airport’s fourth most popular route in 2019, with 429,019 passengers.
London City head of aviation Anne Doyere said: “We are delighted that Swiss has returned to the airport to restore an important business and leisure connection between London City and Zurich.
“Zurich is a key centre for international business, finance and tourism, so this is very positive news for our passengers who can once again enjoy safe and speedy journeys to Zurich direct from the heart of London.”