Tui is to start River Nile cruises served by charter flights from Gatwick and Manchester airport.
A refurbished 145-passenger ship will run seven-night sailings from Luxor striating in November 2024.
Named Tui Al Horeya, the vessel will operate on an all-inclusive basis and include cabins for solo holidaymakers.
Dedicated Egyptologists will feature while facilities on board include a swimming pool, two whirlpools, an entertainment area, restaurant, outdoor dining, lounge bar, wellness studio and a shop.
Two flights a week on Thursdays will operate to serve the ship between November 7, 2024 and April 24, 2025.
Two set excursions will be included within the sailing package price, such as the Temple of Horus in Edfu and the temple of Kom Ombo.
Prices lead-in at £1,399 based on two adults sharing a superior French balcony cabin with flights from Gatwick on December 5, 2024.
Tui Al Horeya will be the fourth in the Tui River Cruise fleet of adult-only ships.
The expansion into Egypt comes on the back of strong demand from customers, with bookings increasing by 40% over last year.
All three European ships will go on sale for festive sailings in winter 2024, including two new seven-night itineraries over New Year’s Eve in Frankfurt and Cologne in addition to an existing Rhine itinerary.
Managing director Chris Hackney said: “Tui River Cruises is going from strength to strength, and we are so excited to introduce this latest offering on the Nile which we are confident our customers will love.
“A cruise along the Nile offers a serene and unforgettable experience with lush landscapes, traditional villages, and other iconic landmarks such as the Luxor and Edfu Temples.
“With year-round sunshine, Egypt is the perfect destination for exploring ancient history and allowing guests to immerse themselves in a once in a lifetime opportunity.
“The name TUI Al Horeya was chosen to ensure we kept local connection to Egypt, as it is our only Tui River Cruise ship which will stay in the one country. TUI Al Horeya in Arabic means ‘freedom’, signifying the freedom the water brings to explore which is a great representation of what river cruising is all about.”