Bmibaby is switching its Belfast base to George Best Belfast City Airport from January.
The low cost carrier is transferring operations from Belfast International Airport in a move described as offering more convenient services to passengers travelling to Northern Ireland.
Flights from Manchester, East Midlands, Birmingham and Cardiff will serve Belfast City from to from January 10.
The Bmibaby flights will supplement sister airline Bmi’s service between Heathrow and Belfast City.
Bmibaby will run up to 48 flights a week from its four UK bases to Belfast City with fares starting at £9.99 one way including taxes.
Bmi chief executive Wolfgang Prock-Schauer said: “Bmi British Midland International has a long and proud connection with Northern Ireland, serving the city of Belfast for over 26 years.
“It makes obvious business sense to have the bmi group airlines serving the same Belfast airport.
“The group’s physical presence at the airport is also increased and customers now have an excellent range of Bmi group UK destinations available to and from Belfast City Airport – the best choice for business and leisure travellers alike.
“The bmi group will now offer up to 89 flights a week from Heathrow and the UK regions to Belfast City Airport.”
The airport’s chief executive Brian Ambrose said: “This is great news not only for the 1,500 people employed here but the wider community who rely on the airport’s continuing success.”