A-Rosa has restarted river cruises in France with the first trip on the Rhone this week.
This follows the resumption of sailings on the Douro, Rhine and Danube last month.
The first cruise departed from Lyon on a seven-night itinerary by A-Rosa Stella.
An extensive health and hygiene concept is being followed by the German company, including minimum social distancing of 1.5 metres on board and intensified hygiene protocols.
Lucia Rowe, managing director of A-Rosa River Cruises UK and Ireland, added:“This is yet another milestone in our return to Europe’s rivers.
“France is one of the most popular and accessible destinations for our UK guests and we can’t wait for them to be able return, just as soon as the FCO advice alters or is lifted.
“Our itineraries on the Rhone pass through the most beautiful places in Provence and the south of France and our ships which sail there are tailor-made for the enjoyment of the typcial savoir-vivre.”
Her comments came less than a week after the Foreign Office advised against all cruise ship travel.
Chief executive Jorg Eichler said: “We have already received really positive feedback from our first guests regarding our trips on the Douro, Rhine and Danube and the straightforward implementation of our hygiene concept.
“We are really pleased that we can now sail on the Rhone again and look forward to welcoming our guests on board for a relaxing and enjoyable holiday.”