Flybe is closing 30 routes, including 14 summer seasonal services, as part of ongoing cost savings measures.
Passengers affected by the route withdrawals are being contacted and offered an alternative Flybe flight where possible or a full refund on their ticket.
Routes to be axed from January are: Belfast City-Paris, Bristol-Jersey, East Midlands-Paris, Exeter-Newcastle, Glasgow-Shannon, Southampton-Hannover and Leeds/Bradford, Cardiff-Glasgow and Paris and Glasgow Paris.
Summer seasonal routes being dropped are: Exeter-Barcelona, Southampton-Barcelona, Belfast City–Jersey, Bristol–Isle of Man, Edinburgh–Knock, Exeter–Nice, Isle of Man-Jersey and Southampton, Jersey–Luton and Newcastle, Limoges-Newcastle, Newquay–Norwich and Southampton-Beziers.
These are in addition to the regional carrier withdrawing from Gatwick from March 30 with the loss of routes to Belfast City, Guernsey, Inverness, Isle of Man, Jersey and Newcastle.
New chief commercial officer Paul Simmons said: “We recently announced that we would be reconfiguring our route network as part of a carefully planned strategy to optimise our operations.
“We have since taken a long hard look at all the routes we fly to make sure that our new schedule is what our customers really want and that they operate at the best possible times for everyone.”
Flybe will operate more than 150 routes from 65 airports in the UK and the rest of Europe as part of its summer 2014 schedule running between March 30 and October 25.