Pacific Asia Travel Association CEO Martin Craigs is stepping down after three years.
The announcement came as part of the formal opening of the 37th PATA Travel Mart in Cambodia.
His final event for PATA will be moderating a panel at a pre-G20 travel conference in Brisbane on November 13.
Current chief operating officer Mario Hardy is to step in as interim CEO from November 1.
Craigs said: “I will let others that I respect be the judge of the next generation transformation that has been delivered in the past three years.
“Rest assured it has been a pleasure to take PATA back to the top table and into profit.”