Cunard has replaced its existing programme on Queen Elizabeth between February and May 2022 with a series of new ex-Southampton itineraries.
The fresh programme includes a voyage to the Canary Islands and the western Mediterranean and a transatlantic sailing through the Panama Canal and up to Vancouver, Canada.
Another sailing is scheduled to go in search of the Northern Lights.
Departures, from February 20 to May 17 next year, are due to go on sale next month.
Passengers booked on the cancelled voyages will be offered a full refund or future cruise credit worth 125% of the standard deposit terms and 100% of any additional monies paid.
Outgoing Cunard president Simon Palethorpe said: “We hope our guests will be inspired to find a little adventure with these new itineraries. In a single short programme, they offer fantastic variety from the opportunity to experience the Northern Lights, to sun kissed Mediterranean shores, to a transit of the Panama Canal.
“To all guests affected by the cancelled voyages we are sorry for the disappointment this will cause and we hope to welcome many back on board.”