Up to 16 flights a week between Southend airport and Glasgow are being introduced from the end of October.
The Essex airport’s sister regional carrier Stobart Air will operate the service with one-way fares starting at £29.99.
Operating under Flybe branding, the jet service from October 29 will complement other new routes to Manchester and Dublin.
Southend hopes to lure travellers away from larger, more congested London-area airports with a 45-minute rail connection to the centre of the capital.
Glyn Jones, CEO of Stobart Aviation, owner of Southend airport said: “We are delighted to start flying these routes and to be offering these daily flights.
“With London airport capacity feeling significant strain we offer a genuinely better alternative as we are a faster and easier airport; which is particularly suited to offer domestic connectivity where time is of the essence for passengers.”