EasyJet plans to resume a limited number of flights on June 15.
The initial schedule will comprise mainly domestic services in the UK and France.
Further routes will be announced over the coming weeks as customer demand increases and lockdown measures across Europe are relaxed.
Passengers and cabin crew will required to wear masks, while disinfectant wipes and hand sanitiser will be available on board.
No in-flight food service will be available on the first wave of flights and aircraft will be subject to enhanced cleaning and disinfection.
The measures have been implemented in consultation with aviation authorities ICAO and the European Aviation Safety Agency (EASA), and in line with government and medical advice, the airline said.
EasyJet will encourage use of its mobile app, which avoids paper boarding passes, and pledged to work with airports to ensure measures recommended by local and European authorities are implemented.
The resumption of flights by the UK budget carrier follows rival Ryanair planning to restore 40% of its normal flying schedule of almost 1,000 flights a day from July 1.
EasyJet chief executive Johan Lundgren said: “I am really pleased that we will be returning to flying in the middle of June.
“These are small and carefully planned steps that we are taking to gradually resume operations.
“We will continue to closely monitor the situation across Europe so that when more restrictions are lifted the schedule will continue to build over time to match demand, while also ensuring we are operating efficiently and on routes that our customers want.”
He added: “The safety and wellbeing of our customers remains our highest priority, which is why we are implementing a number of measures to enhance safety at each part of the journey, from disinfecting the aircraft to requiring customers and crew to wear masks.
“These measures will remain in place for as long as is needed to ensure customers and crew are able to fly safely as the world continues to recover from the impact of the coronavirus pandemic.”