Flights by Flybe from Manston airport in Kent are to be scrapped next spring.
Services to Edinburgh and Belfast will be withdrawn from March 25 due to poor demand.
The decision follows Flybe dropping flights from Manston to Manchester.
The airline’s marketing director Simon Lilley told local newspaper the Isle of Thanet Gazette: “It is with regret that Flybe can confirm it will cease its operations from Manston International Airport with effect from the end of the winter season on March 25, 2012.
“Flybe carefully reviews the viability of all our 200-plus routes on a regular basis looking not only at passenger numbers but also at external cost pressures. This is done not only to monitor where we can offer increased regularity on a given route but also where passenger numbers make a flight uneconomic.
“Our ongoing commitment to Manston has been reliant on the success of the Edinburgh service that we launched in May 2010.
“Despite extensive marketing of this route both in Scotland and throughout SE England, the challenging economic environment with which we are all faced has meant passenger numbers remain at unsustainable levels, and are insufficient to financially justify its continued operation.”
Passengers who have booked flights for next summer will be offered a full refund or alternative flights.