Flybe is to create a base at Cardiff airport in a long-term agreement which will see a raft of new routes.
The airline will serve 11 destinations in the UK and Europe this summer and base two Embraer E195 regional jets at the airport.
One of the 118-seat aircraft will arrive at Cardiff in June and the second in September.
Flights will be offered to Belfast, Cork, Dublin, Düsseldorf, Edinburgh, Faro, Glasgow, Jersey, Munich, Milan Malpensa, and Paris Charles de Gaulle.
Tickets go on sale from tomorrow (Friday) along with the publication of full schedules.
The expansion in Wales will create 50 jobs, including flight crew and ground handling staff.
The development provides a boost for the airport which was acquired by the Welsh government for £52 million in 2013.
Flybe chief executive Saad Hammad said: “We have been looking to find a productive home for our surplus E195 aircraft and we are delighted at this 10-year agreement with Cardiff airport which involves us basing two of these jets there to serve the Welsh market with great value fares and further improving UK regional connectivity.
“We continue to seek solutions for the remaining seven E195 aircraft.”
Cardiff airport chairman Lord Rowe-Beddoe said: “Our customers want greater choice in routes, more frequent services and better value flights.
“This new Flybe base is most welcome news for our passengers as it will bring new destinations and increased services from a popular great-value airline, as well as creating opportunities to encourage more visitors to come to Wales.”
First Minister of Wales, Carwyn Jones, said: “We’ve always said that we want the airport to be a gateway to Wales, as something that will drive our economy by bringing tourists and business to the country.
“We’ve already invested in improving the overall customer experience at Cardiff airport and the new routes to major European destinations, as well as the creation of 50 new jobs, demonstrates Flybe’s commitment to the airport and will help to make it the success we know it can be.”