Virgin Atlantic will add a third weekly service to Cuba during winter and increase the number of flights to Orlando and Las Vegas.
The additional Gatwick to Havana service will operate on Saturdays from November 2016 to March 2017.
Three new flights from Gatwick to Orlando will run from late July and throughout August, operating on Monday, Tuesday and Wednesday.
Two new services from Gatwick to Las Vegas have also been added for September and October and will run on Monday and Wednesday.
Seasonal services to both American cities have also been extended from other UK airports.
Flights from Manchester to Las Vegas will continue until the end of November, with two services per week, and a weekly service will re-start from the beginning of March 2017. A second service will be added in April.
A weekly service from Glasgow to Orlando will now be available until the end of November and again from the start of March 2017.
Virgin’s American services form part of the airline’s Joint Venture with Delta Air Lines, which will be introducing services from Heathrow to Salt Lake City, as well as Edinburgh to New York JFK, in Summer 2016.
Executive vice president, commercial Erik Varwijk, said: “We’re delighted to be offering our customers more choice when flying to some of their favourite destinations.
“Florida and Las Vegas have been enduringly popular with our customers, and Havana is also consistently seeing incredibly high demand, so it makes perfect sense to increase services during the most popular months.”