Stuttgart will become the eighth German city with a direct link to Manchester thanks to flights being introduced by Eurowings.
The German low-cost carrier is reviving a route dropped by Ryanair after four years in 2019.
More than 78,000 passengers flew on the service in the last 12 months it operated.
Eurowings is to re-establish the Stuttgart link on May 6 with four flights a week on Mondays, Thursdays, Fridays and Sundays using Airbus A319 aircraft. Fares start at £39.99 one way.
Other German cities on the Manchester airport network are Berlin, Frankfurt, Hamburg, Munich, Cologne, Dusseldorf and Freiburg.
Airport managing director Chris Woodroofe said: “We are thrilled to be adding another new destination to what is already the most extensive route network of any UK airport outside London, giving our passengers even more choice when planning their next trip.
“Our data shows that Stuttgart is one of the most in-demand destinations that is not already served, so it’s fantastic news that Eurowings will step in and meet that demand.”