Nashville is being added as the 18th transatlantic route operated by Icelandair.
The seasonal summer service from the airline’s Reykjavík hub will run four times a week.
Flights will operate from May 6 until the end of October with connections from 34 points in Europe, including London and Manchester.
The new route follows the airline forging a partnership with US budget carrier Southwest Airlines from 2025 to provide connections initially via the US gateway of Baltimore.
Icelandair chief executive Bogi Nils Bogason said: “We are very pleased to add Nashville to our extensive network in North America, linking Music City to our 34 destinations in Europe.
“We know travellers will greatly benefit from this new service and offer Tennesseans the best options to Iceland and beyond.
“Our new service will also allow travellers connecting through Nashville more choices throughout the US.
“In addition, we encourage passengers travelling to Europe, to take an Icelandair Stopover, and explore our home.”