Tui is to serve Turkey when it returns to Teesside airport next year.
Antalya becomes the second summer destination to feature from the north-east airport in addition to Palma.
Weekly Thursday departures are scheduled from May 26 to September 22, 2022 with bookings open from next week.
Tui’s weekly flights to Majorca will run every Tuesday from May 10 next year.
The UK’s largest operator announced a return to Teesside after nine years last October and Antalya is the 15th route to be secured since the airport was taken back into public ownership two years ago to save it from closure.
Tees Valley mayor Ben Houchen said: “Tui’s first flight hasn’t even taken off yet but next year’s sales are looking so strong they are already committing to more destinations.
“It was a fantastic coup to announce that the UK’s biggest holiday firm is coming back to Teesside and this just proves that with a clear plan we can make the airport the success we all know it can be.
“Our summer 2021 schedule is proving popular despite the ongoing difficulties we all face due to the coronavirus pandemic. It’s clear to see that people are eager to use their airport and get away for great value breaks, and I’m sure many more will jump at the chance to get away to Turkey next year.
“Tui’s increased commitment for summer 2022 is another huge vote of confidence, and we’ll continue to work with the firm to see how we can get people from their doorstep and through our terminal to even more fantastic destinations.”