November was the 13th consecutive record-breaking month for Heathrow.
The west London hub airport handled 5.9 million passengers, with numbers up 3.5% on the same month last year.
This gave a rolling annual total up by 3.2% to 77.8 million passengers despite the number of aircraft movements remaining static.
Latin America was the fastest growing destination as new British Airways flights to Santiago in Chile and increased load factors by Aeromexico also pushed up growth 10%.
Asia was close behind, growing 8% following the start of a daily morning Japan Airlines Boeing 787 Dreamliner service and additional flights by Jet Airways to Mumbai and China Southern to Guangzhou.
Domestic destinations continued to record healthy growth, up nearly 5% in November helped by the airport’s £10 discount on domestic passenger charges.
“Progress on Heathrow’s expansion plans continues, as the newly formed transport select committee began taking oral evidence on the Airports National Policy Statement,” the airport said.