Cypriot carrier Cobalt Air is to start flying to Athens from Gatwick this month.
A twice-weekly Airbus A320 service is scheduled to start on March 31 with fares leading in at £49 one-way.
Departures on Tuesdays and Saturday will complement the airline’s six flights a week between Gatwick and Larnaca.
The Gatwick-Athens route will feature a new business class, with bespoke seats in a two-by-two configuration with a 40-inch pitch.
Cobalt claims it will become the only airline offering a business class cabin between Gatwick and Athens.
Chief executive Andrew Madar said: “We are delighted to have this opportunity to widen our footprint in European aviation and commence direct London to Athens services at the end of this month.
“The travelling public has taken the relatively young Cobalt brand and its ethos to its heart.
“Our presence in Athens is already strong due to our existing services to Larnaca and Paphos from the Greek capital.
“We are very excited to bring additional competition and attractive fares to the London to Athens route.”